How Do Drugs Work? Gamifying Receptor-Ligand Interactions is a pharmacology-based project that focuses on receptor-ligand molecular interactions. Pharmacology tutors at the University of Glasgow discovered that many students struggle with this threshold concept. The main goal of this project was to develop a game prototype that would allow students to gain a better understanding and appreciation of the 3D shape of ligands and their receptor binding sites. In the end, the game prototype became embedded in an application. Creating this application involved two phases of development. The first phase involved developing the game mechanism itself embedded in a simple application. Pilot testing was done to inform further refinements to the application and game. The second phase of development was based on the pilot testing outcomes and resulted in the addition of a learning module on G-Protein Coupled Receptors (GPCRs), the beta-2 adrenergic receptor, and one of its ligands, propranolol.